Broadcaster Press 3 July 12, 2016 www.broadcasteronline.com Weekly Column: A Blueprint For Tax Reform Video Launched About The Use Of Sheep To Treat Neurological Diseases By Rep. Kristi Noem The South Dakota Agricultural Heritage Museum (SDAHM) and the Shepherd's Gift: GM1 for HD launched GM1 Sheep Can Treat Neurological Diseases, an animated video outlining how sheep can play a role in treating neurological diseases. This video débuted in the exhibit The Unspun Tale: Sheep in South Dakota, at the South Dakota Agricultural Heritage Museum, but is now available to view and share on YouTube. The video discusses how sheep with the recessive gene disorder Gangliosidosis have the potential to treat neurological diseases by providing the GM1 Ganglioside molecules (GM1) needed for proper nerve cell function. Patients with Parkinson's, Huntington's and Alzheimer's and other neurologic diseases have a deficiency of GM1 molecules in their nerve cells. The film answers basic questions about the science behind the research into treatment options and explains how people can get involved in bringing this treatment to patients afflicted with these diseases. "We wanted to include information about the GM1 Gangliosidosis research to treat neurological diseases in the exhibit because it uses sheep and research that is being done in South Dakota," stated South Dakota Agricultural Heritage Museum Director Gwen McCausland. "I personally believe it has the potential to both make a huge impact in treating neurological diseases and for the sheep industry. We hope our exhibit introduces new audiences to this research." The South Dakota Agricultural Heritage Museum wrote the narration for the video and worked with SoDak Animation to design the short film. The Shepherd's Gift: GM1 for HD and SDAHM co-sponsored this project. Why Sheep? In the early 1990s, the Italian pharmaceutical company Fidia Pharma Spa, pioneered the development of a drug platform harvesting GM1 from cattle. The company was in phase II of clinical trials to treat Parkinson's disease when Europe had an outbreak of Mad Cow disease, stopping the use of cattle in the process of further development of this drug. At that time veterinarian Dr. Larry Holler, currently of White, S.D., was working on his Ph.D. studying GM1 Gangliosidosis in a new sheep model. When the Mad Cow disease outbreak happened, he realized the potential these sheep had to treat neurologic disease and pursued research using sheep as a safe and viable source of GM1 molecules. In 2012, researchers at the University of Alberta proved that an infusion of GM1 into the brain restored normal motor behavior in mice with Huntington's disease and demonstrated the potential to reverse the damage created by this neurological disease. Dr. Holler's research shows that sheep with Gangliosidosis have up to 40 times the amount of GM1 molecules compared to normal sheep, providing a safe and natural source of GM1 for treatment of neurological diseases. For over 20 years, Dr. Holler and his wife, Sue, have dedicated their life's work to making this research into a viable treatment option. What is GM1? GM1 Ganglioside (GM1) is a natural glyco (sugar) lipid (fat) molecule found in the membrane of cells in all mammals. GM1 molecules are concentrated on cells found in the nervous system. They serve as the communication port for the cell. Other cells, enzymes and viruses attach to a GM1 molecule to communicate complex processes to the cell. Once it is used, the GM1 goes back into the cell to be recycled into new GM1 molecules. What is Gangliosidosis? Gangliosidosis is a genetic disorder where the body lacks the enzyme needed to break down the used GM1 molecules in the cell. The used GM1 molecules fill up the cell, clogging it until the cell stops working, ultimately causing death. Sheep with Gangliosidosis are harvested a few months after birth and the GM1 molecules can be extracted for medicine. Can you raise a whole herd with Gangliosidosis? No. Gangliosidosis is a recessive gene. If two parents are carriers, their offspring have a 25 percent chance of getting this disease, 50 percent chance of being a carrier, or 25 percent chance of being normal. Research is being conducted to increase these percentages. Before the iPhone, the near-universal ownership of a personal computer, and the fall of the Berlin Wall, the United States passed a new, 26,000-page tax code. In the 30 years since, very few reforms have been made to modernize that tax code – only loopholes added that have nearly tripled its size. No wonder 9 out of 10 taxpayers use either a professional tax preparer or computer software to file their taxes. The call for comprehensive tax reform has been made for years and it’s frustrating that it seems as though little has been done. That was one of the reasons I pushed so hard to join the House Ways and Means Committee this Congress. Out of the House of Representatives’ 435 members, what happens to our tax code starts with the 24 majority members of the Ways and Means Committee. That is where I needed to be, so I was grateful to be named to the committee this year – the first South Dakota Representative in history to do so. Earlier this summer, the committee released our blueprint for pro-growth tax reform. Simply put, it is designed to grow families’ paychecks, the workforce, and the American economy. More specifically, the proposal centers around three ideas. First, the tax code should be simpler, fairer, and flatter. Second, it should make it easier to create jobs, raise wages, and expand opportunity. Finally, it should put taxpayers first. This blueprint is all about simplicity. In fact, we tried to make it simple enough that most Americans could do their taxes on a postcard. That meant reducing the amount of tax brackets from seven to three. We then went through and eliminated many of the most damaging add-on taxes, such as the death tax. Finally, we made sure important “milestone” tax breaks remained to help give families peace of mind at critical moments in life, such as going to school, getting a job, raising a family, or planning for retirement. To make it easier to create jobs and raise wages, the proposal offers to cut taxes on small businesses, creating a separate, low tax rate of 25 percent for many on Main Street. Because U.S. businesses currently have to pay the highest corporate tax rate in the world, it also lowers the corporate tax rate to make America a more competitive place to do business. Ensuring taxpayers come first meant we needed to tackle some pretty serious issues within the IRS – an agency that in recent years has allowed millions of taxpayer calls to go unanswered, targeted conservative organizations, and failed to operate in an ethical manner time and again. This blueprint outlines a restructured IRS that is held accountable to the Taxpayer Bill of Rights and set up to provide excellence in customer service. It would also install a new, term-limited commissioner who would be required to administer the new tax code fairly while keeping politics out of the IRS. This blueprint is just the beginning of the conversation. It isn’t perfect or set in stone, but we’ve taken the initiative to draw the outline; now, it’s time to color in the picture. While we included the ideas that so many taxpayers have talked about and urged for years, we’ll continue looking for feedback and insight. The goal is to turn this plan into detailed, comprehensive legislation that can be moved when a new administration takes office in 2017. If a family or business did things like they did in the 80’s, they’d still be relying on a fax machine. The world doesn’t work like that anymore and neither should our tax code. 3 Ways to Celebrate Summer Affordably at Home (StatePoint) Don’t let the potentially high cost of summer fun keep you from enjoying time with family and friends. To help you take advantage of the blue skies and sunshine from your own backyard, the discount experts at Dollar General are providing affordable ideas to celebrate summer. Fabulous, Why isn't this available for patients right now? Frugal Party Planning GM1 molecules are naturally made by mammals and cannot be recreated in a lab. This Planning a summer party causes issues for pharmaceutical companies trying to mass-produce a drug for thousands of patients. It is estimated that it would take one or two sheep with Gangliosidosis to treat one is fun, but it’s even better patient for one year. Multiply this by the number of patients with Parkinson's, Huntington's, when you can save money and other neurological diseases, and that would require millions of sheep. The focus of Dr. Holler's research is creating a viable, safe, plentiful source of GM1 molecules to treat patients. His research has developed a new, verified, ovine (sheep) source for GM1 ganglioside production that will exceed the levels previously found using cattle by 30 to 40 times, and provide needed raw materials for pharmaceutical applications. Is there a large enough supply of sheep? There are many producers open to introducing this recessive gene into their flocks. It all comes down to the economics of supply and demand. When wool was a great source of income, there were millions more sheep than there are today. If this treatment makes it to market, the demand for sheep with Gangliosidosis will increase and may offer an additional value-added product for sheep producers. Path to Approval VERMILLION SUMMER LUNCH MENU The Summer Food Program at Jolley will be serving lunch Monday through Friday from May 31st to July 29th from 11:00 am to 1:00 pm. This meal is FREE to anyone 18 or younger. For more information call 677-7000. Menu listed below is for July 13 - July 19. Menus are subject to change without notice. To get this treatment into the hands of patients, it needs to be approved by the U.S. Food and Drug Administration (FDA). Dr. Steven Hersch, a clinician and researcher at Harvard/Massachusetts General Hospital, has been working with Dr. Holler on this research. In January 2015, the FDA approved the sheep as an acceptable source of GM1 to progress towards an Investigative New Drug (IND) application, which would lead to human clinical trials. The clinical trial phase requires additional funding. Funding needed to pay for the research Wednesday – Super Nachos, is scarce. The Holler family has been utilizing private funding to support the research as part Peas of a grassroots approach. Thursday – Baked Chicken Nuggets, Golden Corn The Shepherds Gift: GM1 for HD The Shepherds Gift: GM1 for HD is a non-profit organization supporting the advancement Friday – Pizza, Baked Beans of GM1 treatment for Huntington's disease and other neurological diseases. Please visit www. Monday – Baked Crispy Chicken Sandwich, Baked theShepherdsGift.org for more information. Tater Tots Tuesday – Super Nachos, Steamed Carrots Dakota Senior Meals Served at The Main Street Center & Town Square, “Meals on Wheels” Please call before 9:00am to schedule or cancel a meal at 624-7868. Menus listed below are July 13 - July 19. Menus are subject to change without notice. All menus are served with whole grain bread and 1% milk unless otherwise noted. Wednesday – Baked Chicken Fried Steak, Mashed Potatoes and Milk Gravy, Peas, Apricots Thursday – Chicken and Dressing Casserole, Carrots, Coleslaw, Seasonal Fresh Fruit Friday – Ham Potato Omelet, Winter Blend, Cinnamon Roll, Plums Monday – Green Bean and Beef Casserole, Potato Rounds, Fresh Fruit Tuesday – Salisbury Steak in Brown Gravy, Mashed Potatoes, Creamed Cabbage, Apricots Ice Cream Social Trinity Lutheran Church of Vermillion Tuesday, July 19th from 5:00-7:00pm Taverns...chips..homemade pies...ice cream Lemonade and coffee Free will offering 816 E. Clark • Vermillion, SD The Vermillion High School Class of 1986 is sponsoring a VHS Alumni 5K Run/Walk on Saturday, July 16th AC SPRINKLER SYSTEMS OF YANKTON Start to finish with one contractor Aaron (605) 665-3963 To register or for more information, please contact Mary Pochop, pochop@rushmore.com outdoor living space. Add a rug to your back patio or deck and a couple of weather-proof coffee tables to make the space more comfortable. Search for garden decorations online to make the space more inviting. Staycation If you’re not traveling, why not bring summer vacation to you? Spend a weekend with your family in the comfort of your backyard and plan activities you can all enjoy. Host a bonfire and create a summer soundtrack to play while outdoors. You can even cook a vacation-inspired meal or grab a book to read and simply relax. Celebrating summer has never been so easy! With some smart planning, an awesome and affordable summer doesn’t need to involve costly travel or expensive hosting. Bring the Inside Outside Take advantage of the beautiful season by creating an affordable, family-friendly To save time and money on your summer needs, visit www.DollarGeneral.com or visit your nearest Dollar General store. Get your ad in the.. Classifieds Today! 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